The herb Boswellia Serrata (which is actually a source of the somewhat 'mythical' frankincense) has been studied widely of late and has been found to contain several unique anti-inflamatory properties.
The active ingredient in Boswellia is 5-Loxin and as a proprietary extract, has been shown to significantly reduce the painful inflammatory symptoms associated with Knee osteoarthritis.
Most pharmaceutical drugs aimed at reducing this type of inflammation target what are called the Cox-1 and Cox-2 inhibitors - these are groups of enzymes which stir up inflammation and therefore pain. The 5-Loxin substance found in Boswellia appears to act in the same way on these same enzyme groups to reduce their activity and thus reduce inflammation.
In a recent study in the US, 75 patients suffering with acute osteoarthritis of the knee joints were given 100mg or 250mg of Boswellia as 5-Loxin or a placebo. Results showed that both dosages of 5-Loxin led to significant and measurable reduction in pain and importantly this allowed greater mobility. It was also found that the patients taking the higher dose (250mg) of 5-Loxin showed benefits from the supplement much faster and with greater cessation of pain and discomfort in a shorter period from onset.
It was also discovered that the Boswellia extract appeared to have an effect on the enzyme Matrix Metalloprotienase which, in knee joints, is involved in the breakdown and renewal of cartilage and synovial fluid.
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